Silymarin as an Anti-Inflammatory and Inhibitor of UV
It is a well-known fact of life that UV light, especially the exposure of the UVA component ، Melanoma and non-melanoma test skin disorders such as skin cancer. Sanskrin such as surface treatment is only to a limited extent effective.
This feeling has led to the investigation of new methods to protect the skin from the harmful effects of solar UV radiation, or "photo carcinogens. In recent years, there has been a lot of interest in the identification of naturally occurring botany, such as celery, which has antioxidants and anti-inflammatory properties ، And that show anti-carcinogenic and anti-mitogenic functionality.
In this light, the benefits of milk medicine have been the subject of intense research by scientists. Although its value as a medicine for many health situations, including dermatological, has been known for more than 2,000 years, Now it's just that science has begun to take seriously the role played by milk stellar and "cellaring" in treating skin damage.
In an experiment conducted at Plaki University in Czechoslovakia ( 1 ), Researchers studied the effects of two components of the technical name ( for the cell album Marianum ) for milk as both of them were preventive as well as skin against the UVA exposure Arrives to treat damage. Their results were positive, it was discovered that these two components - collectively known as "Flavonolgan" - perform many functions, As the increase in the operation of keratinocytes in irradicated cells prevents the production of ROS.
Prevents further reduction of ATP and GSH at the intracellular level, and prevents the peroxidation of membrane lipids. Plus ، When the two components of the Salem Marianum apply, the UVA exposure stops activating the starting Caspus 3 process and reverses. Therefore, the overall picture that has emerged is that Sally's album Marianum is a good candidate to be considered to prevent damage to UV.
An interesting experiment on rats at the University of Alabama in Birmingham was reported in March-April 2008 in the issue of the journal Photochem Photo Biology ( 2 ). Two observations from this research are special compatibility with us. One, these are CD11b + cells, the largest source of oxidative stress in UV-radiated skin, with Slimrin stopping them. Flavonoids also suppress the infiltration of leukocytes which caused UV exposure.
The second important observation is that selamectin not only prevents damage to UV but also acts as a precautionary measure. Another researcher has taken a step forward with the identification of another reversal that this chemical performs on UV action: This reduces the volume of cells that produce H2O2 and produce cytokine interleukin-10, the generation of which is activated by both UV ( 6 ).
Researchers working in the Department of Pharmaceutical Sciences at the University of Colorado ( 3 ) have almost reached the same conclusion. His research has shown the positive effect of Selbin on UVB-inspired DNA damage repair. Another experiment conducted in the Department of Dermatology at the University of Alabama has affected the prevention that allows flavor tumor promoters such as 12-O-tetradcanoylphorbol-13-acetate، Mezerein occurs; benzoyl peroxide and Okadak acid ( 4 ).
Even before or immediately after, the thematic application of Selbenin ، UV irradiation is found to prevent the Temin slow positive cell generation that is included in the UV epidermis ( 5 ). This study also shows that when the silibinin is applied ، When the formation of a re-inspired terminal sunburn cell by UV is also stopped.
A strong case for celery is a strong case of carcinogens and a strong agent in preventing and replacing tumor-affected cancer through two independent research Has been made. In both experiments ( 7 ), and ( 8 ), it is reported that Calvin inhibits cancer cells (ERK1 / 2 Activation ) and promotes benign cells ( JNK1 / 2, p38 ); Making it an effective cancer prevention agent for cancer.
"An article published in the journal "Cancer Research" Another in-depth investigation was conducted on the efficacy of selamectin as a potential intervention agent against Stage I and Stage II tumors ( 9 ). The paper states that the ectal extract of milk has been found to be useful in pressing stage I tumors in particular, reduces edema and inhibits hyperplasia.
Spread index and oxidant state caused by UV radiation. The same result has been reached by an independent group of researchers, who have used a different chemical to cause skin edema in mice ( 10 ).
From the above research in the world ، It can be safely concluded that the stimulation of calamari UV is proving to be very effective in preventing skin damage, And the day can't be far away when this thin sunscreen of milk becomes an important ingredient in lotion.
References
Sobodo A, Zadrillo A, Waltero de, and Vostolov J. Helium Marianum Moderate UVA-induced oxidative damage to flavonolignans that are to Hacket keratinocytes. Jay Dermatol Science. December 2007 48 ( 3 ): 213-24. Epb 2007 August 3.
Katiar SK, Mellet S, and Sharma SD. Selmarine, a taste from milk ( Cell album Marianum L۔ ) Mouse skin infiltration CD11b + inhibits UV-induced oxidative stress by targeting cells. Photochemical photo biol. 2008 Mar-April 84 ( 2 ): 266-71. Apob 2007 November 28.
Singh RP, and Agarwal R. Silibinin method and premature efficacy in skin cancer prevention. Euro J Cancer. September 2005 41 ( 13 ): 1969-79.
Katiar SK. Prevention of calamari and skin cancer: inflammatory, antioxidant and immunomodulating effects. In Jay Oncol. January 2005 ( 1 ): 169-76.
Dhanalakshmi S, Malikarjuna GU, Singh RP, and Agarwal R. Selbin Temine Dull and Dull positive cells and p53-p21 / in the epidermis / A Cip1 regulation prevents skin damage caused by ultraviolet radiation in SKH1 hairless mice. Carcinogenesis. August 25, 2004 ( 8 ): 1459-65. Apob March 2004۔ 19.
Katiar SK. Treatment of plant-flavored calamari, ultraviolet light in mouse skin inhibits stimulating immune and oxidative stress. In Jay Oncol. December 2002 ( 6 ): 1213-22.
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